With our multifaceted team of chemists, engineers, and biologists, the evaluation of novel nanomaterials, specialized coatings, and polymers are our core competency. We provide expertise and a wide range of assays that can be tailored to each material and intended application based on our clients' specific needs.
During biomaterial design, iFyber takes a holistic approach with respect to the end application and selection of individual components making up the final product. We can conduct a technology landscaping effort for our clients, including an intellectual property (IP) landscape, literature review, and proposed regulatory strategy, to identify enabling technologies and outline potential challenges.
iFyber’s diverse staff utilizes a broad set of analytical techniques and state-of-the-art equipment to answer challenging questions regarding the composition and physical characteristics of a given biomaterial quickly and accurately. During physiochemical characterization, we can perform:
- Composition analysis (e.g., NMR, FT-IR, SERs)
- Material equivalence
- Thermalgravimetric analysis and differential scanning calorimetry (TGA/DSC)
- Surface area and particle size
- Porosity, pore size, and interconnectivity
- Mechanical properties – compressive strength, elastic modulus
- Molecular weight (e.g., GPC, MALDI)
- Resorption rate
In addition to evaluating material inputs, iFyber will design and perform product-specific functional testing of the material, such as evaluating mechanical properties, resorption rate, therapeutic ion release, antimicrobial activity, and biocompatibility.
Work with one of our scientists to tailor a characterization method or functional test for your material technology.
WHAT ARE BIOMATERIALS?
Biomaterials are specially designed materials that are used on or within the body. Devices engineered with these materials can interact with the body’s repair mechanisms. This helps the body to heal itself and allow us to lead longer and healthier lives. By stimulating a desired reaction in the body, biomaterials can be used to augment a broad variety of important processes for improved healing such as tissue remodeling, bone regeneration, hemostasis, and cell signaling. Development and study within the diverse field of biomaterials require an equally diverse team of scientists and engineers to successfully navigate the complexities of the materials and associated biomedical applications. iFyber provides expertise in a range of applied areas that are important to the field of biomaterials; these include synthetic chemistry, analytical chemistry, polymers, chemical engineering, nanotechnology, micro- and molecular biology, and cell biology.
Biomaterials design is a multifaceted endeavor, requiring a holistic mindset with respect to the end application and selection of the individual components making up the end product. iFyber digs deep into the biomaterial – often times at the molecular level – without losing sight of the end application. Representative design projects include design and production of nitric oxide-releasing polymers for wound healing applications, design of diagnostic probes for important biomarkers, and development of new hemostatic coatings for fibrous substrates.
iFyber provides expertise and a range of assays that can be tailored to each material and intended application. If necessary, unique methods are developed based on our clients' specific needs. iFyber utilizes a broad set of analytical techniques to answer challenging questions regarding the composition of a given biomaterial. Specific examples include the use of NMR spectroscopy to determine the fate of a biomaterial within a device during the manufacturing process and the use of EPR spectroscopy to assess the effects of gamma/e-beam sterilization on biomaterials.
IN VITRO TESTING
Due to the complex environment in the body, biomaterials must be thoroughly evaluated to ensure they are safe while meeting the specific requirements for each application, such as mechanical properties, resorption rate, therapeutic ion release, antimicrobial activity, and biocompatibility. iFyber has the capacity to study the front-end biomaterial inputs as well as specific functions of the biomaterial in an end product. A particular focus area for iFyber relates to biomaterials and infection, which can be a major clinical threat.