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Why Trace Impurities Matter Early in Development Trace impurities are still too often treated as a late-stage requirement tied to regulatory submission. In medical device development, they are more accurately an early signal of how materials and processes will perform under real conditions. These impurities are small, unintended chemical substances that remain in a material…

A monoclonal antibody may demonstrate strong target engagement, compelling preclinical efficacy, and favorable early safety signals; and yet experience altered functional durability once it reaches diseased human tissue diseased human tissue. In atopic dermatitis (AD), that risk is not theoretical. As the therapeutic landscape grows more competitive, durability and consistency are emerging as strategic differentiators.…

In high-resolution proteomics, sensitivity alone is not enough. Advances in proteomics increasingly demand instruments capable of detecting low-abundance proteins with high sensitivity and reproducibility. At iFyber, the addition of the Vanquish™ Neo UHPLC system from Thermo Scientific offers a way to deliver this performance, enabling researchers the opportunity to elevate their LC-MS workflows by combining…

When you’re trying to detect trace-level peptides or proteins – especially in complex biological matrices like plasma, tissue, or cell lysates – sensitivity becomes everything. In these scenarios, even incremental improvements in signal can be the difference between confident identification and missed data. That’s why nanoflow liquid chromatography (nanoflow LC) plays such a critical role…