Strengthening Proteomics Capabilities with the Vanquish Neo Nano-LC

In high-resolution proteomics, sensitivity alone is not enough. Advances in proteomics increasingly demand instruments capable of detecting low-abundance proteins with high sensitivity and reproducibility. At iFyber, the addition of the Vanquish™ Neo UHPLC system from Thermo Scientific offers a way to deliver this performance, enabling researchers the opportunity to elevate their LC-MS workflows by combining precise chromatography, robust performance, and flexible configurations to support complex proteomic studies.

Here is how the Vanquish Neo strengthens proteomics workflows:

Enhanced Sensitivity at Low-Flow Rates

Low-flow and nanoflow chromatography maximize ionization efficiency and reduce solvent-driven noise in mass spectrometry for proteomics. The Vanquish Neo operates across nano-, capillary-, and micro-flow regimes, enhancing ionization efficiency and detecting low-abundance peptides in complex biological matrices. Its ultra-low gradient delay volume sharpens peak shapes and improves separation quality, enabling confident protein identification and quantitation.

By maintaining consistent low-flow performance, we are able to extract more information from limited or complex samples without compromising data quality or throughput.

Reliable and Reproducible Chromatography Across Studies

In proteomics, consistent chromatography is essential because even small variations in retention time or peak shape can complicate peptide alignment, skew quantitative results, or make comparisons across samples and time points unreliable.

The Vanquish Neo addresses these challenges through advanced flow control, multi-point calibration, low-dead-volume fluidics, and stable gradient delivery. These features deliver run-to-run and batch-to-batch consistency, ensuring data can be confidently compared, validated, and interpreted—critical for high-throughput studies, longitudinal experiments, or complex biomarker discovery projects.

Engineered for Long-Term Stability and Throughput

Proteomics workflows often involve extended runs and continuous operation. For large-scale or multi-day studies, instrument reliability is essential to maintain consistent performance and avoid costly downtime. The Vanquish Neo is equipped with maintenance-free valves and automated cleaning protocols, enabling continuous operation while reducing maintenance interruptions.

This stability reduces downtime, protects data integrity, and supports higher throughput projects while ensuring that research timelines remain on track and results are consistent over extended experimental periods.

Flexible Configurations for Diverse Applications

Proteomics research encompasses a variety of workflows, from discovery-based profiling to targeted quantitation. Beyond performance, the Vanquish Neo’s modular design supports researchers in directly injecting samples, using trap-and-elute, and running tandem setups, allowing them to tailor workflows to specific project needs and integrate seamlessly into real-world laboratory operations.

This adaptability ensures that researchers can optimize their methods for different sample types and experimental goals, improving efficiency and expanding the scope of studies. These practical advantages help keep the focus where it belongs: on data quality and scientific insight rather than instrument management.

Integration with High-Resolution Orbitrap Mass Spectrometry

When researchers pair the Vanquish Neo with high-resolution Orbitrap mass spectrometers, it enables comprehensive proteomic analysis with both qualitative and quantitative capabilities. Seamless LC-MS integration preserves data quality and reliably identifies and measures critical proteins, supporting research decisions with robust and reproducible results.

This LC-MS pairing is particularly powerful for complex proteomics applications, where sensitivity, selectivity, and consistency directly impact biological interpretation and project outcomes.

Reliable, High-Confidence Proteomics with Advanced LC-MS Workflows

By combining the sensitivity and reproducibility of the Vanquish Neo nano-LC with high-resolution Orbitrap mass spectrometry, iFyber’s LC-MS services deliver proteomics data that researchers can trust. This integration supports workflows from biomarker discovery to targeted quantitation, enabling deeper proteome coverage, consistent results, and high-confidence interpretation. With advanced instrumentation and expert workflow design, iFyber ensures that complex proteomics studies generate reliable, actionable insights for both academic and industry clients.

Researchers looking to enhance their proteomics capabilities can contact iFyber’s team to discuss analytical needs and explore how state-of-the-art LC-MS instrumentation, including the Vanquish Neo, can support robust, reproducible, and high-sensitivity studies.